Microcapsules containing Vitamin D3 in oil

Vitamin D3 (cholecalciferol) is a fat-soluble secosteroid (or pro-hormone) that is produced endogenously through exposure to the sun. Aging and inadequate exposure to sunlight cause a lack of vitamin D3, consequently causing reduced bone mineralization.

Vitamin D3 has numerous other functions, first of all homeostasis and the metabolism of calcium and phosphate. It promotes the physiological growth of the skeleton and plays a minor role in the performance of other biological functions.

Borage oil, derived from the seeds of the Borrago Officinalis plant, has numerous uses and is gaining popularity as a natural anti-inflammatory supplement because it features one of the highest amounts of GLA (Gamma Linoleic Acid) among all seed oils. GLA is a type of essential Omega-6 fatty acid that the body cannot produce on its own and therefore needs to take from external sources. As a Polyunsaturated Fatty Acid (PUFA), the GLA contained in borage oil is known for its beneficial antiinflammatory effects as well as for its anti-aging mechanisms [1].

Omega-3 and Omega-6 PUFAs play an important role in treating several diseases because they help control the release of the molecules which are responsible for the body’s inflammatory responses (prostaglandins, leukotrienes and cytokines called interleukins). In addition, GLA has positive effects on cell death (apoptosis) for toxic cells.

Once it enters the body, GLA is converted into Dihomo-γ-linolenic acid (DGLA) which acts as a precursor to the prostaglandins and leukotriene compounds that the immune system produces. DGLA is thought to decrease inflammation because it inhibits the synthesis of leukotrienes, which are partly responsible for increasing autoimmune reactions and thrombotic effects. For this reason, borage oil is used to alleviate the symptoms of various inflammatory and age-related ailments, including arthritis, atopic eczema and some respiratory disorders [2].

"[1]. Institute of Medicine. Dietary reference intakes for calcium and vitamin D. Washington DC: The National Academies Press 2012