2. Home
  3. Info
  4. Case Studies
  5. SANUVIA uses FLOWACTIVES® technology to combine Omega 3 (EPA/DHA) and Vitamin K2 MK7

SANUVIA uses FLOWACTIVES® technology to combine Omega 3 (EPA/DHA) and Vitamin K2 MK7

 

Context

SANUVIA is a company specialized in dietary supplements, commissioned to formulate a new combined supplement based on Omega‑3 (EPA/DHA) and Vitamin K2‑MK7, targeting cardiovascular and bone‑joint health.

 

Initial development issues

The company began testing various standard formulations:

  • Oil-based formulation (traditional softgel)
    • Omega‑3 oxidizesquickly.
    • Vitamin K2‑MK7 degrades in the presence of light and oxygen.
      Result: unstable product after just a few months.
  • Dry formulations (hard capsules, tablets)
    • Technical difficulties in combining a lipid phase (Omega‑3) with a sensitive active (K2) without degradation or loss of bioavailability.
      Result: unstable and poorlyeffective product.
  • Use of antioxidants
    • Antioxidants fail to prevent Omega‑3 oxidation.
    • Vitamin K2 shows degradation interactions with lipid oxidation products.
      Result: poorefficacy and chemicalinstability.

Turning point: IPS’s Flowactives® technology – microencapsulation by coacervation


SANUVIA turned to IPS, which proposed an advanced microencapsulation-by-coacervation solution—the basis of the Flowactives® line.

 

What is coacervation?

It is a physico‑chemical process that encloses active ingredients in a polymeric matrix, creating stable, protective, functional microcapsules.

 

Key advantages of Flowactives® technology

  • Oxidationprotection
    • Actives are isolated from external factors (oxygen, moisture, light).
    • Omega‑3 is stabilized, Vitamin K2 is protected from oxidative products.
  • Physicalseparation of actives
    • EPA/DHA and Vitamin K2‑MK7 are microencapsulated separately, preventing unwanted chemical interactions.
  • Increasedbioavailability
    • Microcapsules enable targeted release in the gastrointestinal tract, enhancing absorption.
  • Formulationversatility
    • Flowactives® microcapsules can be incorporated into hard capsules, sachets, or powders, while maintaining efficacy.

 

Results

Thanks to Flowactives® technology, the final product remains stable, effective, and well tolerated, with positive consumer feedback.

 

References

  • EFSA Journal 2009;7(9):1228. Scientific Opinion on the substantiation of health claims related to EPA and DHA and maintenance of normal blood pressure.
  • Booth SL. (2012). Vitamin K: Food composition and dietary intakes. Food &NutritionResearch, 56.